Oridonin Manufacturer from China

Product name:Oridonin
CAS:28957-04-2
Molecular Formula:C20H28O6
Molecular Weight: 364.43g/mol
Description of Oridonin:
A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED50 ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC50 ~ 5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
Handling: Protect from air and moisture
USAGE: For Research Use Only! Not For Use in Humans.
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