CAS:3895-92-9
Molecular Formula:C21H18ClNO4
Molecular Weight: 383.82g/mol
Description of Chelerythrine:
Chelerythrine is a potent and specific inhibitor of protein kinase C.
Chelerythrine Chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of protein kinase C (IC50=0.66 µM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50=1.5μM. When used in combination with cisplatin (sc-200896) inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown Chelerythrine Chloride was demonstrated to inhibit rabbit platelet aggregation and release.
More about:Chelerythrine online
Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus). It is a potent, selective, and cell-permeable protein kinase C inhibitor. Chelerythrine chloride
回复删除